Gene expression analysis of tumors demonstrates an induction of Th1 type immune response following intratumoral administration of ONCOS-102 in refractory solid tumor patients
نویسندگان
چکیده
Gene expression analysis of tumors demonstrates an induction of Th1 type immune response following intratumoral administration of ONCOS102 in refractory solid tumor patients Mamun Majumder, Ashwini Kumar, Caroline Heckman, Matti Kankainen, Sari Pesonen, Elke Jäger , Julia Karbach , Timo Joensuu, Kalevi Kairemo, Kaarina Partanen, Tuomo Alanko, Akseli Hemminki, Charlotta Backman, Kasper Dienel, Mikael von Euler, Tiina Hakonen, Juuso Juhila, Tuuli Ranki, Lotta Vassilev, Antti Vuolanto, Magnus Jaderberg
منابع مشابه
Phase I study with ONCOS-102 for the treatment of solid tumors – an evaluation of clinical response and exploratory analyses of immune markers
BACKGROUND We conducted a phase I study with a granulocyte macrophage colony stimulating factor (GMCSF)-expressing oncolytic adenovirus, ONCOS-102, in patients with solid tumors refractory to available treatments. The objectives of the study were to determine the optimal dose for further use and to assess the safety, tolerability and adverse event (AE) profile of ONCOS-102. Further, the respons...
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